All the selected papers are at the journal quality in Q1 or Q2.

Scimago Journal & Country Rank
and Quartile Scores (Q1-Q4):
The impact factor (IF) of an academic journal is a measure reflecting the yearly average number of citations to recent articles published in that journal. It is frequently used as a index for the relative importance of a journal within its field; journals with higher impact factors are often deemed to be more important than those with lower ones.

Based on Impact Factor (IF) data, SCImago provides yearly rankings of science and social science journals, in the subject categories relevant for the journal.
Quartile rankings are therefore derived for each journal in each of its subject categories according to which quartile of the IF distribution the journal occupies for that subject category. Q1 denotes the top 25% of the IF distribution, Q2 for middle-high position (between top 50% and top 25%), Q3 middle-low position (top 75% to top 50%), and Q4 the lowest position (bottom 25% of the IF distribution)

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AC. Net 3% + Zn-PCA 1%

Oleanolic acid decrease the secretion of sebum by inhibiting 5a-reductase activity.
Laxminarain Misraa, Hartmut Laatschb (2000). "Triterpenoids, essential oil and photo-oxidative 28 R 13- lactonization of oleanolic acid from Lantana camarap." Phytochemistry54: 969±974.

Nordihydroguaiaretic acid can control the secretion of sebum by curbing 5a-reductase activity.
Richard A. Hiipakka, H.-Z. Z., Wei Dai, Qing Dai, Shutsung Liao* (2002). "Structure±activity relationships for inhibition of human 5a-reductases by polyphenols." Biochemical Pharmacology: 1165-1176.

Nordihydroguaiaretic acid decrease excessive sebaceous activities and increase water contain.
Kim, H. Y., et al. (2012). "Impact on inflammation and recovery of skin barrier by nordihydroguaiaretic Acid as a protease-activated receptor 2 antagonist." Biomol Ther (Seoul)20(5): 463-469.

Zinc can down-regulate the secretion of sebum and the anti-inflammatory and properties of zinc help treat acne for oily skin.
Gupta, M., et al. (2014). "Zinc therapy in dermatology: a review." Dermatol Res Pract2014: 709152.


Ascorbyl Tetraisopalmitate 3%


Ascorbyl Tetraisopalmitateis a stable vitamin C derivative and effectively converts into free vitamin C in the skin to perform whitening property.
Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical vitamin C and the skin: Mechanisms of action and clinical applications. Journal of Clinical and Aesthetic Dermatology, 10, 14–17.
Fernandes, D. and M. Signorini (2008). "Combating photoaging with percutaneous collagen induction." Clin Dermatol26(2): 192-199.


Ascorbyl Tetraisopalmitate suppressed melanocyte proliferation by curbing the secretion of melanocyte proliferation factors IL-1a and PGE2.
Ascorbyl Tetraisopalmitateprevents UV-induced skin pigmentation through its anti-oxidative properties.

Ochiai, Y., et al. (2006). "A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties." Journal of Dermatological Science44(1): 37-44.


Brio (Eye essence)

A copper complex of the tripeptide GHK activated the synthesis of collagen accelerates wound healing and stimulates biological events in tissue repair , enhances the firmness of skinand stimulate tissue repair.
Lintner, K., Peschard, O. 2000Biologically active peptides: from a laboratory bench curiosity to function skin care productInt. J. Cosmet. Sci.22207218

Chrysin can reduce dark circles by increasing bilirubin clearance.
Hesperidin methyl chalcone can reduce puffiness around eyes by strengthen capillaries thus decreasing permeability.
Dipeptide can improve lymphatic circulation and drainage to reduce puffiness around eyes.

Fathi, R., et al. (2015). "Minimally invasive eyelid care in dermatology: medical, laser, and cosmetic therapies." Clin Dermatol33(2): 207-216.

Palmitoyl tripeptide-5 induces production of collagen;reportedly 60% more effective than palmitoyl pentapeptide , and enhances skin elasticity.
Bucay, V. W. and D. Day (2013). "Adjunctive skin care of the brow and periorbital region." Clin Plast Surg40(1): 225-236.


Granactive Retinoid Emulsion 2% + GABA

Retinoid could increase production of collagen and also improve dyschromia, slowing down aging.
Bucay, V. W. and D. Day (2013). "Adjunctive skin care of the brow and periorbital region." Clin Plast Surg40(1): 225-236.

Retinoid could be significant against intrinsic and extrinsic aging.
Mukherjee S, Date A, Patravale V, et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging 2006;1:327–48.

GABA significantly increase skin elasticity and reduce wrinkles.
Ferrillo, M., et al. (2018). "Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use." J Cosmet Laser Ther: 1-6.

Bisabolol improve skin inflammatory and soothe irritated skin.
Rocha NF, Rios ER, Carvalho AM, et al. Anti-nociceptive and anti-inflammatory activities of (􏰁)-a-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:525-533.


Hyaluronic Acid 2% + Na-PCA 1%

Hyaluronic acid are capable of retaining water in amounts up to 1000 times there volume.
Johl SS, Burgett RA. Dermal filler agents: a practical review. Curr Opin Ophthalmol 2006;17(5):471–479

Hyaluronic acid has hydrophilic properties, which is helpful for the hydration and plastic properties of the skin
Sylvie Verdier-Sévrain, M. F. d. r. B., PhD2 (2007). "Skin hydration: a review on its molecular mechanisms." Journal of Cosmetic Dermatology6: 75–82.

Hyaluronic acid could favor tissue hydration, which is a positive effect on skin healing.
Manuskiatti, W, Maibach, HI. Hyaluronic acid and skin: wound healing and aging. Int J Dermatol. 1996;35:539–544.

Low molecular weight Hyaluronic acid penetrates the skin better than larger sized HA and have anti-aging effects.
Farwick, M., et al. (2011). "Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis." Skin Pharmacology and Physiology24(4): 210-217.

Na-PCA help hydrate the skin and improve dry, flaky skin conditions.
Rawlings AV, Canestrari DA, Dobkowski B. Moisturizer technology versus clinical performance. Dermatol Ther. 2004;17(suppl 1):49-56.


Luz (Brightening serum)

Potassium 4-methoxysalicylate whiten skin by inhibiting tyrosinase. (tyrosinase help synthesize melanin)
Ito, S. and K. Wakamatsu (2015). "A convenient screening method to differentiate phenolic skin whitening tyrosinase inhibitors from leukoderma-inducing phenols." Journal of Dermatological Science80(1): 18-24.

Clinical trial demonstrates that tranexamic Acid can significant reduce melanin and melisma level.
Atefi, N., et al. (2017). "Therapeutic Effects of Topical Tranexamic Acid in Comparison with Hydroquinone in Treatment of Women with Melasma." Dermatol Ther (Heidelb)7(3): 417-424.

Nanopeptide significant inhibits production of melanin, whitening skin.
Yang, J., et al. (2011). "pH-responsive hydrogel microparticles as intelligent delivery carriers for α-MSH antagonists." AIChE Journal57(7): 1919-1925.


100% Plant-Derived Squalane

Squalane is more stable than squalene and provides emollient and moisturizing properties.
Kim, S.-K. and F. Karadeniz (2012). Biological Importance and Applications of Squalene and Squalane. Marine Medicinal Foods - Implications and Applications - Animals and Microbes: 223-233.

Squalane oil, indeed, is an emollient and moisturizing; additionally, it is resistant to oxidation, and its use does not require preservatives.
Ciriminna, R., et al. (2014). "Catalytic Hydrogenation of Squalene to Squalane." Organic Process Research & Development18(9): 1110-1115.

A high water containing gel which includes squalane among other naturally derived ingredients has been applied to patients with mild uremic pruritus for 2 weeks. Results showed that skin dryness and itching were significantly improved after 2 weeks of gel treatment. 
Matsumoto, K. O. a. K. (2004). "Effect of Skin Care With an Emollient Containing a High Water Content on Mild Uremic Pruritus." Therapeutic Apheresis and Dialysis.


100% Organic Cold-Pressed Marula Oil

Marula oil contains a similar fatty acid composition to olive oil; however, it is 10 times more stable to oxidation.

Mariod AA, Abdelwahab SI (2012). Sclerocarya birrea (Marula), an African tree of nutritional and medicinal uses: a review. Food Rev. Int. 28(4):375-388.

Marula high content of palmitic acid creates a protective coating on the surface of the skin. The oil absorbs quickly, hydrates the skin, heals skin tissues, reduces redness, reduces transepidermal water loss, increases the smoothness of skin.
A. Mariod, B. Matthäus, Y.A. Idris, S. AbdelwahabFatty acids, tocopherols, phenolics and the antimicrobial effect of Sclerocarya birrea kernels with different harvesting dates Journal of the American Oil Chemists Society, 87 (4) (2010), pp. 377-384

Marula oil contain high content of oleic acid (70-78%), exhibiting good antioxidative properties.
I. Vermaak, G.P.P. Kamatou, B. Komane-Mofokeng, A.M. Viljoen, K.BeckettAfrican seed oils of commercial importance-cosmetic applications S. Afr. J. Bot., 77 (2011), pp. 920-933

The oxidative stability of marula oil is significantly higher than sesame, peanut, sunflower, and cottonseed oils.
Mariod, A.; Matthäus, B.; Eichner, K.; Hussein, I.H. Study of fatty acids, tocopherol, sterols, phenolic compounds and oxidative stability of three unconventional oils in comparison with four conventional ones. Arab J. Food Nutr. 2009, 23, 50–55.


100% Organic Cold-Pressed Rosehip Oil

The rosehip oil has a higher level of polyunsaturated fatty acids such as linoleic acid (54.05%) and linolenic acids (19.37%), precursors of omega-3 and omega-6 fatty acids. Linoleic acid and linolenic acid are major elements of the content of the epidermis, helping construct barrier function of the skin.
Phetcharat, L.; Wongsuphasawat, K.; Winther, K. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clin. Interv. Aging 2015,10, 1849

The rosehip-seed oil had a higher antioxidant capacity compared to the vegetable oils.
Ilyasog ̆lu, H. Characterization of Rosehip (Rosa canina L.) Seed and Seed Oil. Int. J. Food Prop. 2014, 17, 1591–1598.

Rosehip oil has antioxidant effect and improve skin aging.
Lin T-K, Zhong L, Santiago J. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 2017;19(1):70.


Niacinamide 10% + Matrixyl 2%

Clinical trials demonstrate that niacinamide significant reduces fine lines and wrinkles, hyperpigmented spots, red blotchiness, and

skin sallowness. In addition, elasticity of skin was improved.
Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg 2005; 31: 860–865; Discussion 865.

Report demonstrates that the niacinamide-containing moisturizer improved stratum corneum barrier function.
Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005 76:135–141.

Niacinamide has a stabilizing effect on epidermal barrier function and reduce transepidermal water loss, improves the surface
structure, smoothes out wrinkles, reduces hyperpigmentation.
Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol 2004;3:88–93.

Niacinamide reduce skin pore size and improve texture by reducing sebum overproduction.
BissettDL,OblongJE,SaudA,etal.Topicalniacinamideprovidesskin aging appearance benefits while enhancing barrier function. J Clin Dermatol 2003;32S:9-18. Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cos Laser Ther 2006;8:96-101.


A copper complex of the tripeptide GHK activated the synthesis of collagen accelerates wound healing and stimulates biological events in tissue repair , enhances the firmness of skinand stimulate tissue repair.
Lintner, K.,Peschard, O. 2000Biologically active peptides: from a laboratory bench curiosity to function skin care productInt. J. Cosmet. Sci.22207218


Glycolic acid


Clinical trials, collecting 40 Asian candidate, show that glycolic acid results in improving comedones, papules in Asian skin.
Wang CM, Huang CL, Hu CT, Chan HL. The effect of glycolic acid on the treatment of acne in Asian skin. Dermatol Surg. 1997;23:23‐29.

Glycolic acid can be used to peel skin of all skin types with minimal risk.
Moy, L. S., Murad, H., & Moy, R. L. (1993). Glycolic acid peels for the treatment of wrinkles and photoaging. Journal of Dermatologic Surgery and Oncology, 19, 243–246.

30% glycolic acid peels offer successful adjunctive treatment of facial acne vulgaris.
Kessler E, Flanagan K, Chia C et al. Comparison of alpha‐and beta‐hydroxy acid chemical peels in the treatment of mild to moderately severe facial acne vulgaris. Dermatol Surg2008; 34: 45–50; discussion 1.


Lactic acid

The ability of lactic acid to suppress the formation of tyrosinase is responsible for its effects like skin lightening and rejuvenation.
R.P. John, K.M. Nampoothiri, A. Pandey Fermentative production of lactic acid from biomass: an overview on process developments and future perspectives. Appl Microbiol Biotechnol, 74 (2007), pp. 524-534

Lactic acid was found to be an effective and safe peeling agent in thetreatment of melasma.
Sharquie KE, Al‐Tikreety MM, Al‐Mashhadani SA. Lactic acid chemical peels as a new therapeutic modality in melasma in comparison to Jessner’s solution chemical peels. Dermatol Sur2006; 32: 1429–1436.

Lactic acid stimulates ceramide biosynthesis leading to increased stratum corneum ceramide levels which results in superior lipid barrier and a more effective resistance against xerosis.
Rawlings AV, Davies A, Carlomusto M, et al. Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res. 1996;288(7):383–390.


Salicylic acid

Salicylic acid can effectively condition the sebum performance and soften cornea. 
Arif T. Salicylic acid as a peeling agent: a comprehensive review. Clin Cosmet Investig Dermatol 2015;8:455–61

Gel of glycolic acid 15% plus salicylic acid 2% is safe and effective when applied to facial flat warts once daily. After 8 weeks, it is significant improve.
Rodríguez-Cerdeira C, Sánchez-Blanco E. Glycolic acid 15% plus salicylic acid 2%: a new therapeutic pearl for facial flat warts. J Clin Aesthet Dermatol 2011;4:62–64


Mandelic acid

Mandelic acid induces exfoliation of epidermis by reducing corneocyte adhesion. It is a large molecule that penetrates the skin slowly so it is better tolerated on the skinand possesses antibacterial properties.
David E Castillo, Jonette E Keri. Chemical peels in the treatment of acne: patient selection and perspectives. Clin Cosmet Investig Dermatol. 2018; 11: 365–372.

20% mandelic acid plus citric acid boost peels, improve oily and acne-prone skin.
Green et al., 2009B.A. Green, R.J. Yu, E.J. Van ScottClinical and cosmeceutical uses of hydroxyacids. Clinics in Dermatology, 27 (2009), pp. 495-501

Mandelic acid improves different types of acne including comedonal, papulopustular, acne scars, acne-prone oily skin.
Kontochristopoulos G, Platsidaki E. Chemical peels in active acne and acne scars. Clin Dermatol. 2017;35(2):179–182.